A weak association between TH and DRD2 genes and bipolar affective disorder in a Spanish sample.
Copyright policy )A weak association between TH and DRD2 genes and bipolar affective disorder in a Spanish sample.
Genetic factors play an important role in the aetiology of bipolar affective disorder (BP). So far, results of linkage studies have been largely disappointing. We have searched for a possible association between polymorphic DNA markers of two candidate genes (tyrosine hydroxylase, TH; dopamine D2 receptor gene, DRD2) and BP in a population from central Spain. Our results are consistent with the existence of a weak association between these two genes and BP, in such a way that TH and DRD2 could be considered as minor genes contributing to susceptibility.
Adult, Genetic Markers, Male, Bipolar Disorder, Polymorphism, Genetic, Genotype, Tyrosine 3-Monooxygenase, Genetic Linkage, Receptors, Dopamine D2, Middle Aged, Pedigree, Genetics, Population, Gene Frequency, Spain, Case-Control Studies, Humans, Female, Alleles, Repetitive Sequences, Nucleic Acid
Adult, Genetic Markers, Male, Bipolar Disorder, Polymorphism, Genetic, Genotype, Tyrosine 3-Monooxygenase, Genetic Linkage, Receptors, Dopamine D2, Middle Aged, Pedigree, Genetics, Population, Gene Frequency, Spain, Case-Control Studies, Humans, Female, Alleles, Repetitive Sequences, Nucleic Acid
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