Mouse p150Glued(Dynactin 1) cDNA Sequence and Evaluation as a Candidate for the Neuromuscular Disease Mutationmnd2
Copyright policy )Mouse p150Glued(Dynactin 1) cDNA Sequence and Evaluation as a Candidate for the Neuromuscular Disease Mutationmnd2
p150Glued (Dynactin 1) is a component of the dynactin complex that is essential for retrograde axonal transport in neurons. The mouse p150Glued cDNA was isolated from mouse brain by RT-PCR. The complete sequence of the full length mouse cDNA was determined, including 19 bp of 5' UTR, 3843 bp of coding sequence, and 162 bp of 3' UTR. The predicted protein has a molecular mass of 142 kDa and exhibits 95% amino acid sequence identity to the predicted amino acid sequence of human p150Glued (DCTN1). The mouse Dctn1 gene was previously mapped in the central region of mouse chromosome 6, close to the neuromuscular disease gene mnd2. Northern blot analysis, complete sequencing of the cDNA, Western blot, and functional tests of the protein did not detect any abnormalities of p150Glued in mnd2 mice.
- University of Michigan–Ann Arbor United States
- University of Michigan–Flint United States
- University of Pennsylvania United States
DNA, Complementary, Sequence Homology, Amino Acid, Molecular Sequence Data, Dyneins, Dynactin Complex, Neuromuscular Diseases, Mice, Inbred C57BL, Mice, Evaluation Studies as Topic, Mutation, Microtubule Proteins, Animals, Humans, Amino Acid Sequence, Microtubule-Associated Proteins
DNA, Complementary, Sequence Homology, Amino Acid, Molecular Sequence Data, Dyneins, Dynactin Complex, Neuromuscular Diseases, Mice, Inbred C57BL, Mice, Evaluation Studies as Topic, Mutation, Microtubule Proteins, Animals, Humans, Amino Acid Sequence, Microtubule-Associated Proteins
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