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Interaction of Short-Range Repressors with Drosophila CtBP in the Embryo

descriptionPublicationkeyboard_double_arrow_right Article 03 Apr 1998 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science, volume 280, pages 101-104 (issn: 0036-8075, eissn: 1095-9203,

Authors: Yutaka Nibu; Michael Levine; Hailan Zhang;

doi: 10.1126/science.280.5360.101

pmid: 9525852

Interaction of Short-Range Repressors with Drosophila CtBP in the Embryo

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Abstract

Human CtBP attenuates transcriptional activation and tumorigenesis mediated by the adenovirus E1A protein. The E1A sequence motif that interacts with CtBP, Pro-X-Asp-Leu-Ser-X-Lys (P-DLS-K), is present in the repression domains of two unrelated short-range repressors in Drosophila , Knirps and Snail, and is essential for the interaction of these proteins with Drosophila CtBP (dCtBP). A P-element–induced mutation in dCtBP exhibits gene-dosage interactions with a null mutation in knirps , which is consistent with the occurrence of Knirps-dCtBP interactions in vivo. These observations suggest that CtBP and dCtBP are engaged in an evolutionarily conserved mechanism of transcriptional repression, which is used in both Drosophila and mammals.

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University of California, Berkeley
United States

Keywords

Cell Nucleus, Male, Embryo, Nonmammalian, Molecular Sequence Data, Gene Dosage, Genes, Insect, Phosphoproteins, Animals, Genetically Modified, DNA-Binding Proteins, Alcohol Oxidoreductases, Gene Expression Regulation, Genes, Reporter, Mutation, Animals, Drosophila Proteins, Humans, Insect Proteins, Drosophila, Female, Amino Acid Sequence

13 Research products, page 1 of 2

Drosophila melanogaster mRNA for CtBP, complete cds.
2018IsRelatedTo
Knirps, isoform B
2017IsRelatedTo
C-terminal binding protein, isoform H
2017IsRelatedTo
C-terminal binding protein, isoform F
2017IsRelatedTo
C-terminal-binding protein
2017IsRelatedTo
C-terminal binding protein, isoform J
2017IsRelatedTo
Zygotic gap protein knirps
2017IsRelatedTo
C-terminal binding protein, isoform I
2017IsRelatedTo
C-terminal binding protein, isoform B
2018IsRelatedTo
Gal4
2017IsRelatedTo

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