Huwe1-Mediated Ubiquitylation of Dishevelled Defines a Negative Feedback Loop in the Wnt Signaling Pathway
Copyright policy )Huwe1-Mediated Ubiquitylation of Dishevelled Defines a Negative Feedback Loop in the Wnt Signaling Pathway
By ubiquitylating a protein interaction domain in Dishevelled, Huwe1 acts as a negative feedback regulator of Wnt signaling.
- University of Bristol United Kingdom
- University of Greifswald Germany
- Masaryk University Czech Republic
- Czech Academy of Sciences Czech Republic
- Royal Netherlands Academy of Arts and Sciences (KNAW) Netherlands
Ubiquitin-Protein Ligases, Dishevelled Proteins, 610, Mass Spectrometry, Caenorhabditis elegans Proteins/genetics, Animals, Humans, Ubiquitin-Protein Ligases/genetics, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Wnt Signaling Pathway, beta Catenin, Adaptor Proteins, Signal Transducing, Signal Transducing/metabolism, Tumor Suppressor Proteins, Signal Transducing, Ubiquitination, Adaptor Proteins, Phosphoproteins, beta Catenin/metabolism, Phosphoproteins/metabolism, HEK293 Cells, RNA Interference, Caenorhabditis elegans/genetics, Signal Transduction
Ubiquitin-Protein Ligases, Dishevelled Proteins, 610, Mass Spectrometry, Caenorhabditis elegans Proteins/genetics, Animals, Humans, Ubiquitin-Protein Ligases/genetics, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Wnt Signaling Pathway, beta Catenin, Adaptor Proteins, Signal Transducing, Signal Transducing/metabolism, Tumor Suppressor Proteins, Signal Transducing, Ubiquitination, Adaptor Proteins, Phosphoproteins, beta Catenin/metabolism, Phosphoproteins/metabolism, HEK293 Cells, RNA Interference, Caenorhabditis elegans/genetics, Signal Transduction
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