Mitochondrial DNA Variability in Slovaks, with Application to the Roma Origin
Copyright policy )Mitochondrial DNA Variability in Slovaks, with Application to the Roma Origin
SummaryTo gain insight into the mitochondrial gene pool diversity of European populations, we studied mitochondrial DNA (mtDNA) variability in 207 subjects from western and eastern areas of Slovakia. Sequencing of two hypervariable segments, HVS I and HVS II, in combination with screening of coding region haplogroup‐specific RFLP‐markers, revealed that the majority of Slovak mtDNAs belong to the common West Eurasian mitochondrial haplogroups (HV, J, T, U, N1, W, and X). However, a few sub‐Saharan African (L2a) mtDNAs were detected in a population from eastern part of Slovakia. In addition, about 3% of mtDNAs from eastern Slovakia encompass Roma‐specific lineages. By means of complete mtDNA sequencing we demonstrate here that the Roma‐specific M‐lineages observed in gene pools of different Slavonic populations (Slovaks, Poles and Russians), belong to Indian‐specific haplogroups M5a1 and M35. Moreover, we show that haplogroup J lineages found in gene pools of the Roma and some Slavonic populations (Czechs and Slovaks) belong to new subhaplogroup J1a, which is defined by coding region mutation at position 8460.
- Russian Academy of Sciences Russian Federation
- Far East Branch of the Russian Academy of Sciences Russian Federation
- Institute of Biological Problems of the North Russian Federation
- Charles University Czech Republic
- Slovak Medical University Slovakia
Roma, Base Sequence, Molecular Sequence Data, Population Dynamics, Genetic Variation, Sequence Analysis, DNA, DNA, Mitochondrial, White People, Genetics, Population, Haplotypes, Humans, Phylogeny, Polymorphism, Restriction Fragment Length
Roma, Base Sequence, Molecular Sequence Data, Population Dynamics, Genetic Variation, Sequence Analysis, DNA, DNA, Mitochondrial, White People, Genetics, Population, Haplotypes, Humans, Phylogeny, Polymorphism, Restriction Fragment Length
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).40 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!