PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes
Copyright policy )PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes
PBAF and BAF are two chromatin-remodeling complexes of the SWI/SNF family essential for mammalian transcription and development. Although these complexes share eight identical subunits, only PBAF can facilitate transcriptional activation by nuclear receptors in vitro. Here we show that these complexes have selectivity in mediating transcription of different interferon-responsive genes. The selectivity by PBAF requires a novel subunit, BAF200, but not the previously described PBAF-specificity subunit, BAF180 (Polybromo). Our study provides in vivo evidence that PBAF and BAF regulate expression of distinct genes, and suggests that BAF200 plays a key role in PBAF function.
- King’s University United States
- National Institute of Health Pakistan
- National Institute on Aging United States
- National Institutes of Health United States
Chromosomal Proteins, Non-Histone, In Vitro Techniques, Chromatin Assembly and Disassembly, Recombinant Proteins, Protein Subunits, Gene Expression Regulation, Multiprotein Complexes, Interferon Type I, Humans, RNA, Small Interfering, HeLa Cells, Transcription Factors
Chromosomal Proteins, Non-Histone, In Vitro Techniques, Chromatin Assembly and Disassembly, Recombinant Proteins, Protein Subunits, Gene Expression Regulation, Multiprotein Complexes, Interferon Type I, Humans, RNA, Small Interfering, HeLa Cells, Transcription Factors
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