DrhoGEF3 encodes a new Drosophila DH domain protein that exhibits a highly dynamic embryonic expression pattern
Copyright policy )DrhoGEF3 encodes a new Drosophila DH domain protein that exhibits a highly dynamic embryonic expression pattern
The Rho GTPases regulate many different cellular and developmental processes, and activation of Rho GTPase signalling is mediated through interaction with the Dbl homology (DH) protein domain. We describe the expression pattern of DrhoGEF3 (cytological position 61B1-B3), which encodes a new member of the DH domain protein family from Drosophila and is a homologue of the human protein hPEM-2. During gastrulation and germ band extension, DrhoGEF3 exhibits a segmented expression pattern. DrhoGEF3 is subsequently expressed in the visceral mesoderm, at the sites of muscle attachment and in specific groups of sub-epidermal cells. The possible function of such a dynamically expressed signalling molecule is discussed.
- University of Salford United Kingdom
- Wellcome Centre for Cell-Matrix Research United Kingdom
- Wellcome Trust United Kingdom
rho GTP-Binding Proteins, Dbl, DNA, Complementary, Sequence Homology, Amino Acid, Molecular Sequence Data, Protein Structure, Tertiary, Segmentation, Rho, Morphogenesis, Animals, Drosophila Proteins, Guanine Nucleotide Exchange Factors, Humans, Insect Proteins, Drosophila, Amino Acid Sequence, Cloning, Molecular, Signal Transduction
rho GTP-Binding Proteins, Dbl, DNA, Complementary, Sequence Homology, Amino Acid, Molecular Sequence Data, Protein Structure, Tertiary, Segmentation, Rho, Morphogenesis, Animals, Drosophila Proteins, Guanine Nucleotide Exchange Factors, Humans, Insect Proteins, Drosophila, Amino Acid Sequence, Cloning, Molecular, Signal Transduction
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