Three mutant genes cooperatively induce brain tumor formation in drosophila Malignant Brain Tumor

Name: Three mutant genes cooperatively induce brain tumor formation in drosophila Malignant Brain Tumor
Creator: I, Riede
Keywords: Genetic Markers, Male, Recombination, Genetic, 0301 basic medicine, 0303 health sciences, Embryo, Nonmammalian, Genotype, Brain Neoplasms, Chromosome Mapping, Proteins

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1996 English Publisher:Elsevier BVJournal:Cancer Genetics and Cytogenetics, volume 90, pages 135-141 (issn: 0165-4608,

Authors: I, Riede;

doi: 10.1016/s0165-4608(96)00093-3

pmid: 8830723

Three mutant genes cooperatively induce brain tumor formation in drosophila Malignant Brain Tumor

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Abstract

The Drosophila melanogaster strain Malignant Brain Tumor reveals temperature-sensitive transformation of the larval brain tissue. Genetic analysis shows that three gene defects, spzMBT, yetiMBT, and tldMBT, cooperatively induce brain tumor formation. Whereas spz and tld belong to the genes inducing differentiation patterns in the embryo, yeti induces cell overgrowth. spzMBT-, yetiMBT-, and tldMBT-containing animals are larval lethal, whereas Malignant Brain Tumor is kept as a homozygous strain at a permissive temperature. This reveals that this tumor-forming strain is the result of a number of adaptive mutation events.

Keywords

Genetic Markers, Male, Recombination, Genetic, Embryo, Nonmammalian, Genotype, Brain Neoplasms, Chromosome Mapping, Proteins, Cell Differentiation, Genes, Insect, Cell Transformation, Neoplastic, Drosophila melanogaster, Insect Hormones, Larva, Animals, Drosophila Proteins, Insect Proteins, Female, Genes, Tumor Suppressor, Crosses, Genetic

14 Research products, page 1 of 2

Spatzle, isoform J
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Protein groucho
2017IsRelatedTo
Groucho, isoform J
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Protein spaetzle
2017IsRelatedTo
Groucho, isoform H
2017IsRelatedTo
SD20537p
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Spatzle
2018IsRelatedTo
Spz
2017IsRelatedTo
Groucho, isoform I
2017IsRelatedTo
Dorsal-ventral patterning protein tolloid
2017IsRelatedTo

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