Tryptophan scanning mutagenesis as a way to mimic the compound-bound state and probe the selectivity of allosteric inhibitors in cells
Copyright policy )Tryptophan scanning mutagenesis as a way to mimic the compound-bound state and probe the selectivity of allosteric inhibitors in cells
Dominant negative mutants are useful tools in chemical biology, but they do not mimic the action of allosteric inhibitors. We show that properly-placed tryptophan residues can sometimes be superior for this purpose.
570, General Chemistry, 540, Fluorescence, Chemistry, Emerging Infectious Diseases, Infectious Diseases, 5.1 Pharmaceuticals, Fluorescence polarization, Chemical Sciences, Molecular dynamics (MD) simulations, Development of treatments and therapeutic interventions, Infection
570, General Chemistry, 540, Fluorescence, Chemistry, Emerging Infectious Diseases, Infectious Diseases, 5.1 Pharmaceuticals, Fluorescence polarization, Chemical Sciences, Molecular dynamics (MD) simulations, Development of treatments and therapeutic interventions, Infection
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