Heterozygous missense variant of the proteasome subunit β-type 9 causes neonatal-onset autoinflammation and immunodeficiency
Copyright policy )Heterozygous missense variant of the proteasome subunit β-type 9 causes neonatal-onset autoinflammation and immunodeficiency
Abstract Impaired proteasome activity due to genetic variants of certain subunits might lead to proteasome-associated autoinflammatory syndromes (PRAAS). Here we report a de novo heterozygous missense variant of the PSMB9 proteasome subunit gene in two unrelated Japanese infants resulting in amino acid substitution of the glycine (G) by aspartic acid (D) at position 156 of the encoded protein β1i. In addition to PRAAS-like manifestations, these individuals suffer from pulmonary hypertension and immunodeficiency, which are distinct from typical PRAAS symptoms. The missense variant results in impaired immunoproteasome maturation and activity, yet ubiquitin accumulation is hardly detectable in the patients. A mouse model of the heterozygous human genetic variant ( Psmb9 G156D/+ ) recapitulates the proteasome defects and the immunodeficiency phenotype of patients. Structurally, PSMB9 G156D interferes with the β-ring-βring interaction of the wild type protein that is necessary for 20S proteasome formation. We propose the term, proteasome-associated autoinflammatory syndrome with immunodeficiency (PRAAS-ID), to indicate a separate category of autoinflammatory diseases, similar to, but distinct from PRAAS, that describes the patients in this study.
- Hyogo College of Medicine Japan
- Kyoto University Japan
- University of Tokyo Japan
- Okayama University of Science Japan
- Osaka University Japan
Male, Heterozygote, Proteasome Endopeptidase Complex, Science, Hypertension, Pulmonary, Primary Immunodeficiency Diseases, Q, Hereditary Autoinflammatory Diseases, Infant, Newborn, Mutation, Missense, Mice, Transgenic, Syndrome, Article, Pedigree, Cysteine Endopeptidases, Disease Models, Animal, Mice, Animals, Humans, Female
Male, Heterozygote, Proteasome Endopeptidase Complex, Science, Hypertension, Pulmonary, Primary Immunodeficiency Diseases, Q, Hereditary Autoinflammatory Diseases, Infant, Newborn, Mutation, Missense, Mice, Transgenic, Syndrome, Article, Pedigree, Cysteine Endopeptidases, Disease Models, Animal, Mice, Animals, Humans, Female
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