Myosin‐X is required for cranial neural crest cell migration in Xenopus laevis
Copyright policy )Myosin‐X is required for cranial neural crest cell migration in Xenopus laevis
AbstractMyosin‐X (MyoX) belongs to a large family of unconventional, nonmuscle, actin‐dependent motor proteins. We show that MyoX is predominantly expressed in cranial neural crest (CNC) cells in embryos of Xenopus laevis and is required for head and jaw cartilage development. Knockdown of MyoX expression using antisense morpholino oligonucleotides resulted in retarded migration of CNC cells into the pharyngeal arches, leading to subsequent hypoplasia of cartilage and inhibited outgrowth of the CNC‐derived trigeminal nerve. In vitro migration assays on fibronectin using explanted CNC cells showed significant inhibition of filopodia formation, cell attachment, spreading and migration, accompanied by disruption of the actin cytoskeleton. These data support the conclusion that MyoX has an essential function in CNC migration in the vertebrate embryo. Developmental Dynamics 238:2522–2529, 2009. © Published 2009 Wiley‐Liss, Inc.†
- National Institute of Health Pakistan
Gene Expression Regulation, Developmental, Myosins, Oligonucleotides, Antisense, Xenopus Proteins, Xenopus laevis, Phenotype, Cell Movement, Neural Crest, Gene Knockdown Techniques, Cell Adhesion, In Situ Nick-End Labeling, Morphogenesis, Animals, In Situ Hybridization
Gene Expression Regulation, Developmental, Myosins, Oligonucleotides, Antisense, Xenopus Proteins, Xenopus laevis, Phenotype, Cell Movement, Neural Crest, Gene Knockdown Techniques, Cell Adhesion, In Situ Nick-End Labeling, Morphogenesis, Animals, In Situ Hybridization
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