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Genetic variants in a ‘cAMP element binding protein’ (CREB)-dependent histone acetylation pathway influence memory performance in cognitively healthy elderly individuals

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2014 English Publisher:Elsevier BVJournal:Neurobiology of Aging, volume 35, pages 28,810,000,000-28,810,000,000,000 (issn: 0197-4580,

Authors: Scott A. Small; Scott A. Small; Sandra Barral; Sandra Barral; Richard Mayeux; Richard Mayeux; Christiane Reitz; +1 Authors

doi: 10.1016/j.neurobiolaging.2014.06.024

pmid: 25150575

pmc: PMC4253058

Genetic variants in a ‘cAMP element binding protein’ (CREB)-dependent histone acetylation pathway influence memory performance in cognitively healthy elderly individuals

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Abstract

The molecular pathways underlying age-related memory changes remain unclear. There is a substantial genetic contribution to memory performance through life span. A recent study has implicated RbAp48, which mediates its effect on age-related memory decline by interacting with cyclic adenosine monophosphate responsive element binding protein (CREB)1 binding protein and influencing this histone acetylation pathway. To validate these findings, we tested whether genetic variants in RbAp48, CREB1, and CREBBP are associated with memory performance in 3 independent data sets consisting of 2674 cognitively healthy elderly individuals. Genetic variant rs2526690 in the CREBBP gene was significantly associated with episodic memory performance (pmeta = 3.7 × 10(-4)) in a multivariate model adjusted for age, sex, and apolipoprotein E status. Identifying genetic variants that modulate mechanisms of cognitive aging will allow identifying valid targets for therapeutic intervention.

Related Organizations

University of Chicago
United States
Columbia University Medical Center
United States
King’s University
United States

Keywords

Aging, Memory, Episodic, Acetylation, CREB-Binding Protein, Polymorphism, Single Nucleotide, Cohort Studies, Histones, Cognition, Memory, Humans, Retinoblastoma-Binding Protein 4, Cyclic AMP Response Element-Binding Protein, Genetic Association Studies

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