Molecular cloning and localization to chromosome 6 of mouseINT1L1 gene
Copyright policy )Molecular cloning and localization to chromosome 6 of mouseINT1L1 gene
The human INT1L1 gene, which exhibits homology to the protooncogene INT1 is very closely linked to the MET gene and cystic fibrosis locus on human chromosome 7. In the present study we have isolated overlapping genomic clones that correspond to the mouse homolog of the INT1L1 gene and have used the cloned DNA as probes to examine the distribution of the mouse INT1L1 gene within a series of 35 mouse-hamster somatic cell hybrids. These analyses have localized the INT1L1 gene to mouse chromosome 6. In addition, we demonstrate that the mouse INT1L1 and MET genes are coamplified in lines of spontaneously transformed mouse NIH3T3 cells, indicating that these genes may remain closely linked within the mouse genome.
- Imperial College London United Kingdom
- University of East Anglia United Kingdom
- Antoni van Leeuwenhoek Hospital Netherlands
- Netherlands Heart Institute Netherlands
- Institute of Cancer Research United Kingdom
570, Base Sequence, Genetic Linkage, Molecular Sequence Data, Gene Amplification, 610, Chromosome Mapping, DNA, Hybrid Cells, Wnt Proteins, Blotting, Southern, Mice, Proto-Oncogene Proteins, Sequence Homology, Nucleic Acid, Proto-Oncogenes, Animals, Humans, Amino Acid Sequence, Cloning, Molecular, DNA Probes, Cell Line, Transformed, Gene Library
570, Base Sequence, Genetic Linkage, Molecular Sequence Data, Gene Amplification, 610, Chromosome Mapping, DNA, Hybrid Cells, Wnt Proteins, Blotting, Southern, Mice, Proto-Oncogene Proteins, Sequence Homology, Nucleic Acid, Proto-Oncogenes, Animals, Humans, Amino Acid Sequence, Cloning, Molecular, DNA Probes, Cell Line, Transformed, Gene Library
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