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Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes

Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes
The purpose of this study was to determine whether maternal/fetal single nucleotide polymorphisms (SNPs) in candidate genes are associated with spontaneous preterm labor/delivery.A genetic association study was conducted in 223 mothers and 179 fetuses (preterm labor with intact membranes who delivered <37 weeks of gestation [preterm birth (PTB)]), and 599 mothers and 628 fetuses (normal pregnancy); 190 candidate genes and 775 SNPs were studied. Single locus/haplotype association analyses were performed; the false discovery rate was used to correct for multiple testing.The strongest single locus associations with PTB were interleukin-6 receptor 1 (fetus; P=.000148) and tissue inhibitor of metalloproteinase 2 (mother; P=.000197), which remained significant after correction for multiple comparisons. Global haplotype analysis indicated an association between a fetal DNA variant in insulin-like growth factor F2 and maternal alpha 3 type IV collagen isoform 1 (global, P=.004 and .007, respectively).An SNP involved in controlling fetal inflammation (interleukin-6 receptor 1) and DNA variants in maternal genes encoding for proteins involved in extracellular matrix metabolism approximately doubled the risk of PTB.
- National Institute of Health Pakistan
- Vanderbilt University United States
- Wayne State University United States
- Wayne State College United States
- Pontifical Catholic University of Chile. Faculty of Arts Chile
Adult, Fetal Membranes, Premature Rupture, Infant, Newborn, Genetic Variation, Polymorphism, Single Nucleotide, Receptors, Interleukin-6, Extracellular Matrix, Chorioamnionitis, Obstetric Labor, Premature, Haplotypes, Pre-Eclampsia, Pregnancy, Case-Control Studies, Infant, Small for Gestational Age, Humans, Premature Birth, Female, Genetic Predisposition to Disease, Chile, Genetic Association Studies
Adult, Fetal Membranes, Premature Rupture, Infant, Newborn, Genetic Variation, Polymorphism, Single Nucleotide, Receptors, Interleukin-6, Extracellular Matrix, Chorioamnionitis, Obstetric Labor, Premature, Haplotypes, Pre-Eclampsia, Pregnancy, Case-Control Studies, Infant, Small for Gestational Age, Humans, Premature Birth, Female, Genetic Predisposition to Disease, Chile, Genetic Association Studies
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