Hepatocyte growth factor–regulated tyrosine kinase substrate (Hgs) is involved in BMP signaling through phosphorylation of smads and TAK1 in early mouse embryo
Copyright policy )Hepatocyte growth factor–regulated tyrosine kinase substrate (Hgs) is involved in BMP signaling through phosphorylation of smads and TAK1 in early mouse embryo
AbstractHepatocyte growth factor–regulated tyrosine kinase substrate that is encoded by Hgs promotes degradation of ubiquitinated signaling molecule in the early endosome. We previously reported that a targeted mutation in Hgs results in embryonic lethality soon after gastrulation in the mouse. Here, we report that downstream target genes for BMP signaling were highly down‐regulated in the Hgs mutant embryos. We also showed that Hgs is required for phosphorylation of SMAD1/5/8 and TAK1/p38 to transduce BMP signaling. Furthermore, we found that HGS functions to localize TAK1 in early endosome for its activation. These results suggest that HGS is critical to localize TAK1 to early endosome for transducing BMP signaling for proper development. Our data revealed a new mechanism to modify BMP signaling by Hgs during early mouse development. Developmental Dynamics 240:2474–2481, 2011. © 2011 Wiley‐Liss, Inc.
- National Institute of Health Pakistan
- National Institutes of Health United States
- University of Michigan–Flint United States
- Research Triangle Park Foundation United States
- University of Michigan United States
Mice, Knockout, Endosomal Sorting Complexes Required for Transport, Gastrulation, Embryonic Development, Smad Proteins, Bone Morphogenetic Protein 4, MAP Kinase Kinase Kinases, Phosphoproteins, Pediatrics, Models, Biological, Mice, Protein Transport, Blastocyst, Health Sciences, Bone Morphogenetic Proteins, Endosome, Animals, Tissue Distribution, Phosphorylation, Signal Transduction
Mice, Knockout, Endosomal Sorting Complexes Required for Transport, Gastrulation, Embryonic Development, Smad Proteins, Bone Morphogenetic Protein 4, MAP Kinase Kinase Kinases, Phosphoproteins, Pediatrics, Models, Biological, Mice, Protein Transport, Blastocyst, Health Sciences, Bone Morphogenetic Proteins, Endosome, Animals, Tissue Distribution, Phosphorylation, Signal Transduction
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