Identification and characterization of heart-specific splicing of human neurexin 3 mRNA (NRXN3)
Copyright policy )Identification and characterization of heart-specific splicing of human neurexin 3 mRNA (NRXN3)
Three neurexin (NRXN) genes are known in humans, each transcribed from two promoters and extensively spliced at five canonical positions, thus generating thousands of isoforms. For NRXN3, only neuronal expression was reported so far. We reported here on the expression of NRXN3 in additional tissues (lung, pancreas, heart, placenta, liver, and kidney) and on the identification and characterization of heart-specific splicing variants of NRXN3. Cardiac isoforms of NRXN3 probably participate in a complex involving dystroglycan and proteins of extracellular matrix, involved in intercellular connections.
- University of Padua Italy
Male, Myocardium, Amino Acid Motifs, Molecular Sequence Data, Nerve Tissue Proteins, Protein Structure, Tertiary, Alternative Splicing, Humans, Protein Isoforms, Tissue Distribution, Amino Acid Sequence, RNA Splice Sites, RNA, Messenger
Male, Myocardium, Amino Acid Motifs, Molecular Sequence Data, Nerve Tissue Proteins, Protein Structure, Tertiary, Alternative Splicing, Humans, Protein Isoforms, Tissue Distribution, Amino Acid Sequence, RNA Splice Sites, RNA, Messenger
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).20 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!