Distinct transcriptional outputs associated with mono- and dimethylated histone H3 arginine 2
Copyright policy )Distinct transcriptional outputs associated with mono- and dimethylated histone H3 arginine 2
Dimethylation of histone H3 Arg2 (H3R2me2) maintains transcriptional silencing by inhibiting Set1 mediated trimethylation of H3K4. Here we demonstrate that Arg2 is also monomethylated (H3R2me1) in yeast but that its functional characteristics are distinct from H3R2me2: (i) H3R2me1 does not inhibit histone H3 Lys4 (H3K4) methylation; (ii) it is present throughout the coding region of genes; and (iii) it correlates with active transcription. Collectively, these results indicate that different H3R2 methylation states have defined roles in gene expression.
- Wellcome Trust United Kingdom
- EMBL - European Bioinformatics Institute
- Wellcome Trust Genome Campus
- European Molecular Biology Laboratory Germany
- European Bioinformatics Institute United Kingdom
nonhuman, gene deletion, article, protein processing, nucleotide sequence, arginine, Saccharomyces cerevisiae, Arginine, Methylation, Histones, priority journal, histone H3, gene activity, protein protein interaction, Gene Expression Regulation, Fungal, silencer element, gene expression, sporogenesis, gene mutation, methylation, transcription regulation
nonhuman, gene deletion, article, protein processing, nucleotide sequence, arginine, Saccharomyces cerevisiae, Arginine, Methylation, Histones, priority journal, histone H3, gene activity, protein protein interaction, Gene Expression Regulation, Fungal, silencer element, gene expression, sporogenesis, gene mutation, methylation, transcription regulation
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