Ran GTPase protein promotes human pancreatic cancer proliferation by deregulating the expression of Survivin and cell cycle proteins
Copyright policy )Ran GTPase protein promotes human pancreatic cancer proliferation by deregulating the expression of Survivin and cell cycle proteins
Ran, a member of the Ras GTPase family, has important roles in nucleocytoplasmic transport. Herein, we detected Ran expression in pancreatic cancer and explored its potential role on tumour progression. Overexpressed Ran in pancreatic cancer tissues was found highly correlated with the histological grade. Downregulation of Ran led to significant suppression of cell proliferation, cell cycle arrest at the G1/S phase and induction of apoptosis. In vivo studies also validated that result. Further studies revealed that those effects were at least partly mediated by the downregulation of Cyclin A, Cyclin D1, Cyclin E, CDK2, CDK4, phospho-Rb and Survivin proteins and up regulation of cleaved Caspase-3.
- Air Force Medical University China (People's Republic of)
- State Key Laboratory of Cancer Biology China (People's Republic of)
Male, Caspase 3, Survivin, G1 Phase, Down-Regulation, Cell Cycle Proteins, Middle Aged, Inhibitor of Apoptosis Proteins, S Phase, Pancreatic Neoplasms, Mice, ran GTP-Binding Protein, Cell Line, Tumor, Animals, Humans, Female, Cell Proliferation
Male, Caspase 3, Survivin, G1 Phase, Down-Regulation, Cell Cycle Proteins, Middle Aged, Inhibitor of Apoptosis Proteins, S Phase, Pancreatic Neoplasms, Mice, ran GTP-Binding Protein, Cell Line, Tumor, Animals, Humans, Female, Cell Proliferation
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