Changes in platelet GPIbα and ADAM17 during the acute stage of atherosclerotic ischemic stroke among Chinese
Copyright policy )Changes in platelet GPIbα and ADAM17 during the acute stage of atherosclerotic ischemic stroke among Chinese
Glycoprotein (GP) Ibα ectodomain shedding has important implications for thrombosis and hemostasis. A disintegrin and metalloproteinase 17 (ADAM17) was identified to play an essential role in agonist induced GPIbα shedding. The relationship of GPIbα shedding and ADAM17 in the acute stage of atherosclerotic ischemic stroke (AIS) patients has not been thoroughly studied. A total of 306 patients and 230 controls matched for age, sex, race, history of hypertension and diabetes mellitus were enrolled in the study. GPIbα, ADAM17, glycocalicin were detected by flow cytometry, Western blotting, and enzyme-linked immunosorbent assay (ELISA) respectively. Compared with the control group, the expression of GPIbα in patients with acute ischemic stroke was significantly lower (P=0.000, P0.05). GPIbα and National Institute of Health Stroke Scale (NIHSS) had negative correlation (r=-0.514, P<0.01). Our findings indicate that ADAM17 may be a risk factor for ischemic stroke in Chinese and the expression of GPIbα can serve as a measure for stroke severity.
- Huazhong University of Science and Technology China (People's Republic of)
- Union Hospital China (People's Republic of)
Blood Platelets, Male, China, Reproducibility of Results, ADAM17 Protein, Middle Aged, Intracranial Arteriosclerosis, Sensitivity and Specificity, Severity of Illness Index, Brain Ischemia, Stroke, ADAM Proteins, Platelet Glycoprotein GPIb-IX Complex, Humans, Female, Biomarkers
Blood Platelets, Male, China, Reproducibility of Results, ADAM17 Protein, Middle Aged, Intracranial Arteriosclerosis, Sensitivity and Specificity, Severity of Illness Index, Brain Ischemia, Stroke, ADAM Proteins, Platelet Glycoprotein GPIb-IX Complex, Humans, Female, Biomarkers
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