Pooled genetic analysis reveals an association of snps of only a few genes with risk predisposition to ischemic stroke in a Chinese population
Copyright policy )Pooled genetic analysis reveals an association of snps of only a few genes with risk predisposition to ischemic stroke in a Chinese population
AbstractUp to date, series of studies on ischemic stroke had resulted in inconsistent conclusion. In this study, we aimed to evaluate which specific genes were associated with increased predisposition to stroke in a Chinese population. To identify the specific genes and polymorphisms associated with predisposition to ischemic stroke, we performed high throughput sequenom based next‐generation sequencing from 743 patient with history of ischemic stroke. Variants SNPs in nNOS, renalase, MTHFR, CELSR1 and XYLB genes were found significantly associated with IS, thus suggesting involvement of these loci to IS in Chinese patients. Because of different locations on chromosomes, haplotype analyses were not feasible. Our results demonstrate the top level genes that are related to normal vascular physiology, viz. genes of nitric oxide synthesis, endothelial health and smooth muscle biology. Further validation studies are awaited. © 2015 IUBMB Life, 67(3):170–174, 2015
- Lanzhou University China (People's Republic of)
Nitric Oxide Synthase Type I, Cadherins, Polymorphism, Single Nucleotide, Stroke, Phosphotransferases (Alcohol Group Acceptor), Asian People, Ischemia, Humans, Genetic Predisposition to Disease, Monoamine Oxidase, Methylenetetrahydrofolate Reductase (NADPH2)
Nitric Oxide Synthase Type I, Cadherins, Polymorphism, Single Nucleotide, Stroke, Phosphotransferases (Alcohol Group Acceptor), Asian People, Ischemia, Humans, Genetic Predisposition to Disease, Monoamine Oxidase, Methylenetetrahydrofolate Reductase (NADPH2)
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).3 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!