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PubMed Central
Other literature type . 2022
Data sources: PubMed Central
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Journal of Virology
Article . 2022 . Peer-reviewed
Data sources: Crossref
https://doi.org/10.1101/2022.0...
Article . 2022 . Peer-reviewed
Data sources: Crossref
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A Bispecific Antibody Targeting RBD and S2 Potently Neutralizes SARS-CoV-2 Omicron and Other Variants of Concern

Authors: Mengqi Yuan; Xiangyu Chen; Yanzhi Zhu; Xiaoqing Dong; Yan Liu; Zhaohui Qian; Lilin Ye; +1 Authors

A Bispecific Antibody Targeting RBD and S2 Potently Neutralizes SARS-CoV-2 Omicron and Other Variants of Concern

Abstract

The new, highly contagious SARS-CoV-2 Omicron variant caused substantial breakthrough infections and has become the dominant strain in countries across the world. Omicron variants usually bear high mutations in the spike protein and exhibit considerable escape of most potent neutralization monoclonal antibodies and reduced efficacy of current COVID-19 vaccines.

Related Organizations
Keywords

SARS-CoV-2, Antibodies, Monoclonal, Antibodies, Viral, Antibodies, Neutralizing, COVID-19 Drug Treatment, Epitopes, Neutralization Tests, Vaccines and Antiviral Agents, Antibodies, Bispecific, Spike Glycoprotein, Coronavirus, Humans

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    24
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
Powered by OpenAIRE graph
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
24
Top 10%
Average
Top 10%
Green