Nuclear Receptor 4a3 (Nr4a3) Regulates Murine Mast Cell Responses and Granule Content
Copyright policy )Nuclear Receptor 4a3 (Nr4a3) Regulates Murine Mast Cell Responses and Granule Content
Nuclear receptor 4a3 (Nr4a3) is a transcription factor implicated in various settings such as vascular biology and inflammation. We have recently shown that mast cells dramatically upregulate Nuclear receptor 4a3 upon activation, and here we investigated the functional impact of Nuclear receptor 4a3 on mast cell responses. We show that Nuclear receptor 4a3 is involved in the regulation of cytokine/chemokine secretion in mast cells following activation via the high affinity IgE receptor. Moreover, Nuclear receptor 4a3 negatively affects the transcript and protein levels of mast cell tryptase as well as the mast cell's responsiveness to allergen. Together, these findings identify Nuclear receptor 4a3 as a novel regulator of mast cell function.
- Baylor College of Medicine United States
- Swedish University of Agricultural Sciences Sweden
- University of Kentucky United States
Science, Blotting, Western, Apoptosis, Bone Marrow Cells, Nerve Tissue Proteins, Cytoplasmic Granules, Real-Time Polymerase Chain Reaction, Mice, Animals, Mast Cells, RNA, Messenger, Cells, Cultured, Cell Proliferation, Mice, Knockout, Receptors, IgE, Q, R, NF-kappa B, Immunoglobulin E, DNA-Binding Proteins, Mice, Inbred C57BL, Medicine, Cytokines, Chemokines, Research Article
Science, Blotting, Western, Apoptosis, Bone Marrow Cells, Nerve Tissue Proteins, Cytoplasmic Granules, Real-Time Polymerase Chain Reaction, Mice, Animals, Mast Cells, RNA, Messenger, Cells, Cultured, Cell Proliferation, Mice, Knockout, Receptors, IgE, Q, R, NF-kappa B, Immunoglobulin E, DNA-Binding Proteins, Mice, Inbred C57BL, Medicine, Cytokines, Chemokines, Research Article
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