Runx1 and Runx3 Are Downstream Effectors of Nanog in Promoting Osteogenic Differentiation of the Mouse Mesenchymal Cell Line C3H10T1/2
Copyright policy )Runx1 and Runx3 Are Downstream Effectors of Nanog in Promoting Osteogenic Differentiation of the Mouse Mesenchymal Cell Line C3H10T1/2
Previously, we reported that the transcription factor Nanog, which maintains the self-renewal of embryonic stem cells (ESCs), promotes the osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2 through a genome reprogramming process. In the present study, to clarify the mechanism underlying the multipotency of mesenchymal stem cells (MSCs) and to develop a novel approach to bone regenerative medicine, we attempted to identify the downstream effectors of Nanog in promoting osteogenic differentiation of mouse mesenchymal cells. We demonstrated that Runx1 and Runx3 are the downstream effectors of Nanog, especially in the early and intermediate osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2.
- Nihon University Japan
- University of Tokyo Japan
- Nihon Bunka University Japan
Homeodomain Proteins, Mesenchymal Stem Cells, Nanog Homeobox Protein, Cell Line, Mice, Core Binding Factor Alpha 3 Subunit, Osteogenesis, Core Binding Factor Alpha 2 Subunit, Animals, Signal Transduction
Homeodomain Proteins, Mesenchymal Stem Cells, Nanog Homeobox Protein, Cell Line, Mice, Core Binding Factor Alpha 3 Subunit, Osteogenesis, Core Binding Factor Alpha 2 Subunit, Animals, Signal Transduction
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