Molecular Mechanism of HIV-1 Entry
Copyright policy )Molecular Mechanism of HIV-1 Entry
HIV-1 envelope glycoprotein [Env; trimeric (gp160)3 cleaved to (gp120/gp41)3] attaches the virion to a susceptible cell and induces fusion of viral and cell membranes to initiate infection. It interacts with the primary receptor CD4 and coreceptor (e.g., chemokine receptor CCR5 or CXCR4) to allow viral entry by triggering large structural rearrangements and unleashing the fusogenic potential of gp41 to induce membrane fusion. Recent advances in structural biology of HIV-1 Env and its complexes with the cellular receptors have revealed molecular details of HIV-1 entry and yielded new mechanistic insights. In this review, I summarize our latest understanding of the HIV-1 membrane fusion process and discuss possible pathways for productive viral entry.
- Boston Children's Hospital United States
- Harvard University United States
Models, Molecular, Life Cycle Stages, Receptors, CXCR4, Receptors, CCR5, HIV Infections, Virus Internalization, Membrane Fusion, HIV Envelope Protein gp160, CD4 Antigens, HIV-1, Protein Interaction Domains and Motifs
Models, Molecular, Life Cycle Stages, Receptors, CXCR4, Receptors, CCR5, HIV Infections, Virus Internalization, Membrane Fusion, HIV Envelope Protein gp160, CD4 Antigens, HIV-1, Protein Interaction Domains and Motifs
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