A Mouse Speciation Gene Encodes a Meiotic Histone H3 Methyltransferase
Copyright policy )A Mouse Speciation Gene Encodes a Meiotic Histone H3 Methyltransferase
Speciation genes restrict gene flow between the incipient species and related taxa. Three decades ago, we mapped a mammalian speciation gene, hybrid sterility 1 ( Hst1 ), in the intersubspecific hybrids of house mouse. Here, we identify this gene as Prdm9 , encoding a histone H3 lysine 4 trimethyltransferase. We rescued infertility in male hybrids with bacterial artificial chromosomes carrying Prdm9 from a strain with the “fertility” Hst1 f allele. Sterile hybrids display down-regulated microrchidia 2B ( Morc2b ) and fail to compartmentalize γH2AX into the pachynema sex (XY) body. These defects, seen also in Prdm9 -null mutants, are rescued by the Prdm9 transgene. Identification of a vertebrate hybrid sterility gene reveals a role for epigenetics in speciation and opens a window to a hybrid sterility gene network.
- Cornell University United States
- Institute of Molecular Genetics Russian Federation
- Department of Biological Sciences Russian Federation
- Czech Academy of Sciences Czech Republic
Male, Chromosomes, Artificial, Bacterial, Mice, Inbred C3H, Genetic Speciation, Molecular Sequence Data, Chromosome Mapping, Mice, Transgenic, Histone-Lysine N-Methyltransferase, Methylation, Epigenesis, Genetic, Histones, Meiosis, Mice, Gene Expression Regulation, Animals, Hybridization, Genetic, Female, Amino Acid Sequence, Crosses, Genetic, Infertility, Male
Male, Chromosomes, Artificial, Bacterial, Mice, Inbred C3H, Genetic Speciation, Molecular Sequence Data, Chromosome Mapping, Mice, Transgenic, Histone-Lysine N-Methyltransferase, Methylation, Epigenesis, Genetic, Histones, Meiosis, Mice, Gene Expression Regulation, Animals, Hybridization, Genetic, Female, Amino Acid Sequence, Crosses, Genetic, Infertility, Male
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