Molecules and Cells

Article . 2008 . Peer-reviewed

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Molecules and Cells

Article . 2008

Data sources: Europe PubMed Central

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Attenuated Neuropathic Pain in Cav3.1 Null Mice

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2008 English Publisher:Elsevier BVJournal:Molecules and Cells, volume 25, pages 242-246 (issn: 1016-8478,

Authors: Heung Sik, Na; Soonwook, Choi; Junesun, Kim; Joonoh, Park; Hee-Sup, Shin;

doi: 10.1016/s1016-8478(23)17576-5

pmid: 18414012

Attenuated Neuropathic Pain in Cav3.1 Null Mice

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Abstract

To assess the role of alpha(1G) T-type Ca2+ channels in neuropathic pain after L5 spinal nerve ligation, we examined behavioral pain susceptibility in mice lacking CaV3.1 (alpha1G(-/-)), the gene encoding the pore-forming units of these channels. Reduced spontaneous pain responses and an increased threshold for paw withdrawal in response to mechanical stimulation were observed in these mice. The alpha1G(-/-) mice also showed attenuated thermal hyperalgesia in response to both low-(IR30) and high-intensity (IR60) infrared stimulation. Our results reveal the importance of alpha(1G) T-type Ca2+ channels in the development of neuropathic pain, and suggest that selective modulation of alpha1G subtype channels may provide a novel approach to the treatment of allodynia and hyperalgesia.

Related Organizations

Korean Association Of Science and Technology Studies
Korea (Republic of)
Korea University
Korea (Republic of)

Keywords

Mice, Inbred C57BL, Calcium Channels, T-Type, Mice, Infrared Rays, Reaction Time, Animals, Neuralgia, Pain Measurement

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