The T393C polymorphism of GNAS1 as a predictor for chemotherapy sensitivity and survival in advanced non-small-cell lung cancer patients treated with gemcitabine plus platinum
Copyright policy )The T393C polymorphism of GNAS1 as a predictor for chemotherapy sensitivity and survival in advanced non-small-cell lung cancer patients treated with gemcitabine plus platinum
The GNAS1 gene is linked to proapoptotic signaling and correlates closely with clinical outcomes in many human cancers. The aim of this study was to evaluate whether the T393C polymorphism of the GNAS1 gene could be used as a chemotherapy sensitivity and prognosis predictive marker of advanced non-small-cell lung cancer (NSCLC) treated with gemcitabine plus platinum (GP).In this study, we performed the PCR-restriction fragment length polymorphism assay to examine the genotypes of the GNAS1 T393C polymorphism in 131 peripheral blood DNA specimens from advanced NSCLC patients with GP treatment.The frequencies of the CC, CT, and TT genotypes in 131 advanced NSCLC cases were 25.2, 47.4, and 26.7%, respectively. The favorable TT genotype was significantly correlated with better overall survival (OS; P < 0.05) and longer progress-free survival (PFS; P < 0.05) compared with the CT or CC genotype. In the multivariate Cox proportional hazards model, the GNAS1 T393C polymorphism was independently associated with overall survival after adjusting the clinicopathological factors (P < 0.05).This study suggests that the TT genotype of the GNAS1 T393C polymorphism could be an independent prognostic marker to predict chemotherapy sensitivity, favorable OS and PFS in advanced NSCLC patients with GP treatment.
- Hangzhou Cancer Hospital China (People's Republic of)
- University of Hong Kong China (People's Republic of)
- Zhejiang Ocean University China (People's Republic of)
- Zhejiang Cancer Hospital China (People's Republic of)
- University of Hong Kong (香港大學) China (People's Republic of)
Adult, Male, Lung Neoplasms, Genotype, Lung Neoplasms - drug therapy - genetics - mortality - pathology, 610, Deoxycytidine, Disease-Free Survival, Carboplatin, Genetic, Carcinoma, Non-Small-Cell Lung - drug therapy - genetics - mortality - pathology, Carcinoma, Non-Small-Cell Lung, Antineoplastic Combined Chemotherapy Protocols, Chromogranins, GTP-Binding Protein alpha Subunits, Gs, Humans, Polymorphism, Aged, Proportional Hazards Models, Gs - genetics, Polymorphism, Genetic, Carcinoma, Middle Aged, Prognosis, GTP-Binding Protein alpha Subunits, Non-Small-Cell Lung - drug therapy - genetics - mortality - pathology, Female, Cisplatin, Antineoplastic Combined Chemotherapy Protocols - therapeutic use, Polymorphism, Restriction Fragment Length, GTP-Binding Protein alpha Subunits, Gs - genetics
Adult, Male, Lung Neoplasms, Genotype, Lung Neoplasms - drug therapy - genetics - mortality - pathology, 610, Deoxycytidine, Disease-Free Survival, Carboplatin, Genetic, Carcinoma, Non-Small-Cell Lung - drug therapy - genetics - mortality - pathology, Carcinoma, Non-Small-Cell Lung, Antineoplastic Combined Chemotherapy Protocols, Chromogranins, GTP-Binding Protein alpha Subunits, Gs, Humans, Polymorphism, Aged, Proportional Hazards Models, Gs - genetics, Polymorphism, Genetic, Carcinoma, Middle Aged, Prognosis, GTP-Binding Protein alpha Subunits, Non-Small-Cell Lung - drug therapy - genetics - mortality - pathology, Female, Cisplatin, Antineoplastic Combined Chemotherapy Protocols - therapeutic use, Polymorphism, Restriction Fragment Length, GTP-Binding Protein alpha Subunits, Gs - genetics
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