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CtBP, an Unconventional Transcriptional Corepressor in Development and Oncogenesis

Name: CtBP, an Unconventional Transcriptional Corepressor in Development and Oncogenesis
Creator: G Chinnadurai
Keywords: 0301 basic medicine, 0303 health sciences, BRCA1 Protein, Macromolecular Substances, Amino Acid Motifs, Gene Expression Regulation, Developmental, Acetylation, Cell Biology, Oncogenes, Phosphoproteins

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2002 English Publisher:Elsevier BVJournal:Molecular Cell, volume 9, pages 213-224 (issn: 1097-2765,

Authors: G Chinnadurai;

doi: 10.1016/s1097-2765(02)00443-4

pmid: 11864595

CtBP, an Unconventional Transcriptional Corepressor in Development and Oncogenesis

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Abstract

CtBP family proteins are conserved among vertebrates and invertebrates and function as transcriptional corepressors. They repress transcription in a histone deacetylase-dependent or -independent manner. CtBPs play important roles during development and oncogenesis. In this review, their unusual properties, the mechanisms of transcriptional repression, regulation, and their biological functions are discussed.

Related Organizations

Washington State University
United States

Keywords

BRCA1 Protein, Macromolecular Substances, Amino Acid Motifs, Gene Expression Regulation, Developmental, Acetylation, Cell Biology, Oncogenes, Phosphoproteins, Histone Deacetylases, MDS1 and EVI1 Complex Locus Protein, DNA-Binding Proteins, Histones, Alcohol Oxidoreductases, Cell Transformation, Neoplastic, Drosophila melanogaster, Animals, Drosophila Proteins, Humans, Adenovirus E1A Proteins, Phosphorylation, Molecular Biology, Conserved Sequence

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	467
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 1%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 0.1%