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Folic acid-mediated fibrosis is driven by C5a receptor 1-mediated activation of kidney myeloid cells

Authors: Ranjit K. Sahu; Sandhya Xavier; Daniel Chauss; Luopin Wang; Claude Chew; Ronald Taylor; William B. Stallcup; +5 Authors

Folic acid-mediated fibrosis is driven by C5a receptor 1-mediated activation of kidney myeloid cells

Abstract

This study used novel green fluorescent protein C5a receptor 1 floxed mice and the model of folic acid-mediated kidney fibrosis to demonstrate the pathogenic role of increased expression of this complement receptor on macrophages.

Keywords

Mice, Knockout, Green Fluorescent Proteins, Kidney, Fibrosis, Cicatrix, Mice, Folic Acid, Animals, Myeloid Cells, Receptors, Platelet-Derived Growth Factor, Receptor, Anaphylatoxin C5a

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    12
    popularity
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    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
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    Top 10%
Powered by OpenAIRE graph
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
12
Top 10%
Average
Top 10%