The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell development
Copyright policy )The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell development
ABSTRACT Fatty acid binding proteins (FABPs) are a multigene family of small intracellular proteins that bind hydrophobic ligands. In this report we describe the cloning and expression pattern of a novel member of this gene family that is specifically expressed in the developing and adult nervous system and thus was designated brain (B)-FABP. B-FABP is closely related to heart (H)-FABP with 67% amino acid identity. B-FABP expression was first detected at mouse embryonic day 10 in neuroepithelial cells and its pattern correlates with early neuronal differentiation. Upon further development, B-FABP was confined to radial glial cells and immature astrocytes. B-FABP mRNA and protein were found in glial cells of the peripheral nervous system such as satellite cells of spinal and cranial ganglia and ensheathing cells of the olfactory nerve layer from as early as embryonic day 11 until adulthood. In the adult mouse brain, B-FABP was found in the glia limitans, in radial glial cells of the hippocampal dentate gyrus and Bergman glial cells. These findings suggest a function of B-FABP during neurogenesis or neuronal migration in the developing nervous system. The partially overlapping expression pattern with that of cellular retinoid binding proteins suggests that B-FABP is involved in the metabo-lism of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development.
- Helmholtz Association of German Research Centres Germany
- Max Delbrück Center for Molecular Medicine Germany
- National Institutes of Health United States
- National Institute of Mental Health United States
- Freie Universität Berlin Germany
Central Nervous System, Neurons, Base Sequence, Fatty Acids, Molecular Sequence Data, Gene Expression, Epithelial Cells, Mice, Inbred Strains, Nerve Tissue Proteins, Fatty Acid-Binding Proteins, Neoplasm Proteins, Mice, Animals, Amino Acid Sequence, Carrier Proteins, Fatty Acid-Binding Protein 7, Neuroglia
Central Nervous System, Neurons, Base Sequence, Fatty Acids, Molecular Sequence Data, Gene Expression, Epithelial Cells, Mice, Inbred Strains, Nerve Tissue Proteins, Fatty Acid-Binding Proteins, Neoplasm Proteins, Mice, Animals, Amino Acid Sequence, Carrier Proteins, Fatty Acid-Binding Protein 7, Neuroglia
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