The SAND domain protein ULTRAPETALA1 acts as a trithorax group factor to regulate cell fate in plants
Copyright policy )The SAND domain protein ULTRAPETALA1 acts as a trithorax group factor to regulate cell fate in plants
During development, trithorax group (trxG) chromatin remodeling complexes counteract repression by Polycomb group (PcG) complexes to sustain active expression of key regulatory genes. Although PcG complexes are well characterized in plants, little is known about trxG activities. Here we demonstrate that the Arabidopsis SAND (Sp100, AIRE-1, NucP41/75, DEAF-1) domain protein ULTRAPETALA1 (ULT1) functions as a trxG factor that counteracts the PcG-repressive activity of CURLY LEAF. In floral stem cells, ULT1 protein associates directly with the master homeotic locus AGAMOUS, inducing its expression by regulating its histone methylation status. Our analysis introduces a novel mechanism that mediates epigenetic switches controlling post-embryonic stem cell fates in plants.
- United States Department of Agriculture United States
- University of California, Berkeley United States
- Plant Gene Expression Center United States
Histones, Arabidopsis Proteins, Gene Expression Regulation, Plant, Arabidopsis, Cell Differentiation, Methylation, AGAMOUS Protein, Arabidopsis, Epigenesis, Genetic, Transcription Factors
Histones, Arabidopsis Proteins, Gene Expression Regulation, Plant, Arabidopsis, Cell Differentiation, Methylation, AGAMOUS Protein, Arabidopsis, Epigenesis, Genetic, Transcription Factors
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