THE GENETICS OF α-HYDROXYACID OXIDASE AND ALCOHOL DEHYDROGENASE IN THE MOUSE: EVIDENCE FOR MULTIPLE GENE LOCI AND LINKAGE BETWEEN Hao-2 AND Adh-3
Copyright policy )THE GENETICS OF α-HYDROXYACID OXIDASE AND ALCOHOL DEHYDROGENASE IN THE MOUSE: EVIDENCE FOR MULTIPLE GENE LOCI AND LINKAGE BETWEEN Hao-2 AND Adh-3
ABSTRACT Electrophoretic polymorphisms for stomach alcohol dehydrogenase (ADH-C2) and kidney L-α-hydroxyacid oxidase (HAOX-B4) have been identified in an Asian subspecies of mouse, Mus musculus castaneous. These variants are inherited in a normal Mendelian fashion with two alleles in each case showing codominant expression. The structural gene loci for those enzymes (Adh-3 and Hao-2, respectively) are apparently linked (17.6% recombinants) in this organism, whereas the multiple gene loci for HAOX, Hao-1 (encoding the A4 liver isozyme) and Hao-2, exhibited independent segregation and are unlinked (50% recombinants). Evidence is presented for 3 ADH loci: Adh-1, encoding liver ADH-A2 which exhibits high activity with ethanol (Selander, Hunt and Yang 1969; Adh-2, liver and stomach ADH-B 2 using 2-hexene-1-ol as substrate; and Adh-3, stomach ADH-C 2 using both benzyl alcohol and 2-hexene-1-ol as substrate.
- Griffith University Australia
Male, Polymorphism, Genetic, Genotype, Genetic Linkage, Mice, Inbred Strains, Kidney, Isoenzymes, Alcohol Oxidoreductases, Mice, Genes, Liver, Animals, Female, Alleles
Male, Polymorphism, Genetic, Genotype, Genetic Linkage, Mice, Inbred Strains, Kidney, Isoenzymes, Alcohol Oxidoreductases, Mice, Genes, Liver, Animals, Female, Alleles
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