TNIP1/ANXA6 and CSMD1 variants interacting with cigarette smoking, alcohol intake affect risk of psoriasis
Copyright policy )TNIP1/ANXA6 and CSMD1 variants interacting with cigarette smoking, alcohol intake affect risk of psoriasis
Psoriasis is a common multi-factorial skin disease, in which gene-gene and gene-environment interactions may affect the onset, manifestation and clinical course.To investigate the underlying gene-environment interaction among several established susceptibility genes, cigarette smoking and alcohol intake.Using a two-stage case-control design, we searched for pairwise interactions between cigarette smoking and alcohol intake respectively with 9 single nucleotide polymorphisms (SNPs) at ERAP1, PTTG1, CSMD1, GJB2, SERPINB8, ZNF816A and TNIP1/ANXA6 that have been associated with risk for psoriasis in 7,223 subjects. Multiple logistic regression analysis was used for data analysis.Significant interactions were found for alcohol intake with rs3762999 (p=0.0257) and rs999556 (p=0.0071) at TNIP/ANXA6; and for cigarette smoking with rs7007032 (p=0.0023) and rs10088247 (p=0.0023) at CSMD1.This study provides empirical evidence for the gene-environment interactions between TNIP1/ANXA6 and alcohol use, CSMD1 and cigarette smoking, highlighting the importance of gene-environment interactions in the pathogenesis of psoriasis.
- Anhui Medical University China (People's Republic of)
Adult, Male, Alcohol Drinking, Tumor Suppressor Proteins, Smoking, Membrane Proteins, Polymorphism, Single Nucleotide, Connexins, Connexin 26, DNA-Binding Proteins, Logistic Models, Risk Factors, Case-Control Studies, Humans, Psoriasis, Female, Gene-Environment Interaction, Genetic Predisposition to Disease, Annexin A6
Adult, Male, Alcohol Drinking, Tumor Suppressor Proteins, Smoking, Membrane Proteins, Polymorphism, Single Nucleotide, Connexins, Connexin 26, DNA-Binding Proteins, Logistic Models, Risk Factors, Case-Control Studies, Humans, Psoriasis, Female, Gene-Environment Interaction, Genetic Predisposition to Disease, Annexin A6
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