Sp1 transcription factor is required for in vitro basal and Tat-activated transcription from the human immunodeficiency virus type 1 long terminal repeat
Copyright policy )Sp1 transcription factor is required for in vitro basal and Tat-activated transcription from the human immunodeficiency virus type 1 long terminal repeat
Sp1-DNA binding sites have been reported to be essential for basal and Tat-activated transcription of the human immunodeficiency virus type 1 long terminal repeat (LTR). The role of the Sp1 transcription factor itself in regulation of the retroviral LTR, however, has not been clearly defined. It is now known, for instance, that the Sp1-DNA binding sites function also as thyroid hormone receptor response elements (V. Desay-Yajnik and H. H. Samuels, Mol. Cell. Biol. 13:5057-5069, 1993). In this report, we present data that demonstrate a strict requirement for Sp1 for both basal transcription and Tat-mediated trans activation of the human immunodeficiency virus type 1 LTR in vitro.
- Duke University Medical Center United States
- Duke University Health System United States
- Duke Medical Center United States
- Duke University United States
- Duke University Hospital United States
Cell Nucleus, Gene Expression Regulation, Viral, Transcription, Genetic, Sp1 Transcription Factor, Adenoviruses, Human, Chromatography, Ion Exchange, Gene Products, tat, HIV-1, Humans, tat Gene Products, Human Immunodeficiency Virus, RNA Polymerase II, Promoter Regions, Genetic, HeLa Cells, Repetitive Sequences, Nucleic Acid
Cell Nucleus, Gene Expression Regulation, Viral, Transcription, Genetic, Sp1 Transcription Factor, Adenoviruses, Human, Chromatography, Ion Exchange, Gene Products, tat, HIV-1, Humans, tat Gene Products, Human Immunodeficiency Virus, RNA Polymerase II, Promoter Regions, Genetic, HeLa Cells, Repetitive Sequences, Nucleic Acid
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).79 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!