2′-5′-Oligoadenylate synthetase single-nucleotide polymorphisms and haplotypes are associated with variations in immune responses to rubella vaccine
Copyright policy )2′-5′-Oligoadenylate synthetase single-nucleotide polymorphisms and haplotypes are associated with variations in immune responses to rubella vaccine
Interferon-induced antiviral genes are crucial players in innate antiviral defense and potential determinants of immune response heterogeneity. We selected 114 candidate single-nucleotide polymorphisms (SNPs) from 12 antiviral genes using an LD tagSNP selection approach and genotyped them in a cohort of 738 school children immunized with two doses of rubella vaccine. Associations between SNPs/haplotypes and rubella virus-specific immune measures were assessed using linear regression methodologies. We identified 23 significant associations (p < 0.05) between polymorphisms within the 2'-5'-oligoadenylate synthetase (OAS) gene cluster, and rubella virus-specific IL-2, IL-10, IL-6 secretion, and antibody levels. The minor allele variants of three OAS1 SNPs (rs3741981/Ser162Gly, rs1051042/Thr361Arg, rs2660), located in a linkage disequilibrium block of functional importance, were significantly associated with an increase in rubella virus-specific IL-2/T(h)1 response (p
- Mayo Clinic United States
- Mayo Clinic United States
- MAYO CLINIC
- MAYO CLINIC ROCHESTER
- MAYO CLINIC COLL OF MEDICINE, ROCHESTER
Male, Adolescent, Genotype, DNA Mutational Analysis, Vaccination, Immunity, Th1 Cells, Polymorphism, Single Nucleotide, Article, Young Adult, 2',5'-Oligoadenylate Synthetase, Cytokines, Humans, Female, Genetic Predisposition to Disease, Rubella Vaccine, Child, Antigens, Viral, Rubella virus, Genetic Association Studies, Rubella
Male, Adolescent, Genotype, DNA Mutational Analysis, Vaccination, Immunity, Th1 Cells, Polymorphism, Single Nucleotide, Article, Young Adult, 2',5'-Oligoadenylate Synthetase, Cytokines, Humans, Female, Genetic Predisposition to Disease, Rubella Vaccine, Child, Antigens, Viral, Rubella virus, Genetic Association Studies, Rubella
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