Lozenge directly activates argos and klumpfuss to regulate programmed cell death
Copyright policy )Lozenge directly activates argos and klumpfuss to regulate programmed cell death
We show that reducing the activity of the Drosophila Runx protein Lozenge (Lz) during pupal development causes a decrease in cell death in the eye. We identified Lz-binding sites in introns of argos (aos) and klumpfuss (klu) and demonstrate that these genes are directly activated targets of Lz. Loss of either aos or klu reduces cell death, suggesting that Lz promotes apoptosis at least in part by regulating aos and klu. These results provide novel insights into the control of programmed cell death (PCD) by Lz during Drosophila eye development.
- Columbia University United States
- King’s University United States
- Howard Hughes Medical Institute United States
Binding Sites, Green Fluorescent Proteins, Computational Biology, Gene Expression Regulation, Developmental, Apoptosis, Electrophoretic Mobility Shift Assay, Epistasis, Genetic, Nerve Tissue Proteins, Genomics, Immunohistochemistry, Models, Biological, DNA-Binding Proteins, In Situ Nick-End Labeling, Animals, Drosophila Proteins, Drosophila, Photoreceptor Cells, Invertebrate, Eye Proteins, Transcription Factors
Binding Sites, Green Fluorescent Proteins, Computational Biology, Gene Expression Regulation, Developmental, Apoptosis, Electrophoretic Mobility Shift Assay, Epistasis, Genetic, Nerve Tissue Proteins, Genomics, Immunohistochemistry, Models, Biological, DNA-Binding Proteins, In Situ Nick-End Labeling, Animals, Drosophila Proteins, Drosophila, Photoreceptor Cells, Invertebrate, Eye Proteins, Transcription Factors
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