N-terminal acetylation targets GTPases to membranes

Name: N-terminal acetylation targets GTPases to membranes
Creator: Catherine L. Jackson
Keywords: 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, 3. Good health

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2004 English Publisher:Springer Science and Business Media LLCJournal:Nature Cell Biology, volume 6, pages 379-380 (issn: 1465-7392, eissn: 1476-4679,

Authors: Catherine L. Jackson;

doi: 10.1038/ncb0504-379

N-terminal acetylation targets GTPases to membranes

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Abstract

The small GTPases Arl3p and Arl1p function sequentially to recruit diverse effector proteins to the Golgi apparatus. Similarly to ARF proteins, Arl1p is targeted to membranes by myristoylation. Arl3p, however, is not myristoylated. Recent work demonstrates that Arl3p, and its mammalian orthologue ARFRP1, are targeted to membranes by amino-terminal acetylation, which facilitates recognition by the membrane receptor Sys1p/hSys1.

Related Organizations

National Institutes of Health
United States
National Institute of Health
Pakistan

5 Research products, page 1 of 1

The ARF-like GTPases Arl1p and Arl3p Act in a Pathway that Interacts with Vesicle-Tethering Factors at the Golgi Apparatus
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Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p
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Golgi Recruitment of GRIP Domain Proteins by Arf-like GTPase 1 Is Regulated by Arf-like GTPase 3
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Membrane Traffic: Arl GTPases Get a GRIP on the Golgi
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Golgi targeting of ARF-like GTPase Arl3p requires its Nα-acetylation and the integral membrane protein Sys1p
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N-terminal acetylation targets GTPases to membranes

N-terminal acetylation targets GTPases to membranes

5 Research products, page 1 of 1

The ARF-like GTPases Arl1p and Arl3p Act in a Pathway that Interacts with Vesicle-Tethering Factors at the Golgi Apparatus

Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p

Golgi Recruitment of GRIP Domain Proteins by Arf-like GTPase 1 Is Regulated by Arf-like GTPase 3

Membrane Traffic: Arl GTPases Get a GRIP on the Golgi

Golgi targeting of ARF-like GTPase Arl3p requires its Nα-acetylation and the integral membrane protein Sys1p