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FEBS Letters
Article . 2004 . Peer-reviewed
License: Wiley Online Library User Agreement
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FEBS Letters
Article . 2004
Data sources: Europe PubMed Central
https://dx.doi.org/10.1016/j.f...
Article
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University of Surrey Open Research repository
Article . 2004
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Interactions of 12‐lipoxygenase with phospholipase A2isoforms following platelet activation through the glycoprotein VI collagen receptor

descriptionPublicationkeyboard_double_arrow_right Article 18 Sep 2004 United Kingdom English Publisher:WileyJournal:FEBS Letters, volume 576, pages 165-168 (issn: 0014-5793, eissn: 1873-3468, Copyright policy )Funded by:WT | unidentified
Authors: Coffey, M.J.; Coles, B.; Locke, M.; Bermudez-Fajardo, A.; Williams, P.C.; Jarvis, Gavin; O'Donnell, V.B.;

doi: 10.1016/j.febslet.2004.09.007

pmid: 15474031

Interactions of 12‐lipoxygenase with phospholipase A2isoforms following platelet activation through the glycoprotein VI collagen receptor

Abstract

Recent studies implicate the collagen receptor, glycoprotein VI (GPVI) in activation of platelet 12‐lipoxygenase (p12‐LOX). Herein, we show that GPVI‐stimulated 12‐hydro(peroxy)eicosatetraenoic acid (H(P)ETE) synthesis is inhibited by palmityl trifluromethyl ketone or oleyloxyethylphosphocholine , but not bromoenol lactone, implicating secretory and cytosolic, but not calcium‐independent phospholipase A2(PLA2) isoforms. Also, following GPVI activation, 12‐LOX co‐immunoprecipitates with both cytosolic and secretory PLA2(sPLA2). Finally, venoms containing sPLA2acutely activate p12‐LOX in a dose‐dependent manner. This study shows that platelet 12‐H(P)ETE generation utilizes arachidonate substrate from both c‐ and sPLA2and that 12‐LOX functionally associates with both PLA2isoforms.

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United Kingdom
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Keywords

Blood Platelets, Receptors, Collagen, /dk/atira/pure/subjectarea/asjc/1300/1312, 12-Lipoxygenase, Blotting, Western, 610, Platelet Membrane Glycoproteins, Arachidonate 12-Lipoxygenase, Glycoprotein VI, Phospholipases A, Phospholipase A2, Humans, Protein Isoforms, name=Biophysics, 12-Hydro(peroxy)eicosa-tetraenoic acid, /dk/atira/pure/subjectarea/asjc/1300/1303, Platelet, name=Biochemistry, 600, name=Molecular Biology, Platelet Activation, Precipitin Tests, Isoenzymes, Phospholipases A2, /dk/atira/pure/subjectarea/asjc/1300/1304

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
14
Average
Average
Average
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