Nogo 3′-untranslated region CAA insertion: failure to replicate association with schizophrenia and demonstration of marked population difference in frequency of the insertion
Copyright policy )Nogo 3′-untranslated region CAA insertion: failure to replicate association with schizophrenia and demonstration of marked population difference in frequency of the insertion
Novak et al. [Brain Res. Mol. Brain Res. 107 (2002) 183] reported that a CAA insertion in the 3'-untranslated region of the Nogo gene was associated with schizophrenia. We examined the frequency of this CAA insertion in 57 European American subjects with schizophrenia and 243 controls, and in a smaller group of African American subjects (N=72; 20 with schizophrenia). We found a similar frequency of the CAA insertion for patients and controls in both populations, but a large difference in CAA insertion frequency between the two racial groups.
- University of Connecticut United States
Chi-Square Distribution, Genotype, Nogo Proteins, Molecular Sequence Data, Linkage Disequilibrium, Black or African American, Mutagenesis, Insertional, Gene Frequency, Untranslated Regions, DNA Transposable Elements, Schizophrenia, Humans, Myelin Proteins
Chi-Square Distribution, Genotype, Nogo Proteins, Molecular Sequence Data, Linkage Disequilibrium, Black or African American, Mutagenesis, Insertional, Gene Frequency, Untranslated Regions, DNA Transposable Elements, Schizophrenia, Humans, Myelin Proteins
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