Deregulation of ETS1 and FLI1 contributes to the pathogenesis of diffuse large B-cell lymphoma
Copyright policy )Deregulation of ETS1 and FLI1 contributes to the pathogenesis of diffuse large B-cell lymphoma
Key Points A recurrent gain of a region of chromosome 11 (11q24.3) occurs in up to one-quarter of cases of diffuse large B-cell lymphoma. ETS1 and FLI1 genes are overexpressed and determine proliferation, survival, and differentiation arrest of the lymphoma cells.
Chromatin Immunoprecipitation, Proto-Oncogene Protein c-fli-1, Chromosomes, Human, Pair 11, Blotting, Western, 610, Flow Cytometry, Real-Time Polymerase Chain Reaction, Transfection, Immunohistochemistry, Proto-Oncogene Protein c-ets-1, Electroporation, 615, Humans, Lymphoma, Large B-Cell, Diffuse, Transcriptome, Oligonucleotide Array Sequence Analysis
Chromatin Immunoprecipitation, Proto-Oncogene Protein c-fli-1, Chromosomes, Human, Pair 11, Blotting, Western, 610, Flow Cytometry, Real-Time Polymerase Chain Reaction, Transfection, Immunohistochemistry, Proto-Oncogene Protein c-ets-1, Electroporation, 615, Humans, Lymphoma, Large B-Cell, Diffuse, Transcriptome, Oligonucleotide Array Sequence Analysis
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