Pharmacogenetic Interactions Between ABCB1 and SLCO1B1 Tagging SNPs and the Effectiveness of Statins in the Prevention of Myocardial Infarction
Copyright policy )Pharmacogenetic Interactions Between ABCB1 and SLCO1B1 Tagging SNPs and the Effectiveness of Statins in the Prevention of Myocardial Infarction
Genetic variability within the SLCO1B1 and ABCB1 transporter genes has been associated with modification of statin effectiveness in cholesterol management.We conducted a case-control study using a population-based registry of pharmacy records linked to the hospital discharge records. Within a hypercholesterolemic cohort, we included 668 myocardial infarction cases and 1217 controls.We tested 24 tagging SNPs and found two SNPs within ABCB1 (rs3789244, p = 0.01; rs1922242, p = 0.01) to interact with statin treatment. In addition, we found a nonsignificant haplotype-treatment interaction (p = 0.054). The odds ratio for subjects homozygous for SLCO1B1*1A was 0.49 (95% CI: 0.34-0.71) compared with 0.31 (95% CI: 0.24-0.41) for heterozygous or noncarriers of the *1A allele.This is the first study to demonstrate that common genetic variability within the SLCO1B1 and ABCB1 genes is associated with the modification of the effectiveness of statins in the prevention of the clinical outcome, myocardial infarction.
- Erasmus University Rotterdam Netherlands
- Utrecht University Netherlands
- Center for Human Genetics United States
- The University of Texas Health Science Center at Houston United States
- The University of Texas System United States
EMC NIHES-01-64-03, Male, ATP Binding Cassette Transporter, Subfamily B, EMC NIHES-01-64-02, EMC NIHES-03-77-02, Myocardial Infarction, Organic Anion Transporters, Polymorphism, Single Nucleotide, Medical Records, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Polymorphism, P-Glycoproteins, Liver-Specific Organic Anion Transporter 1, Incidence, P-Glycoprotein, Single Nucleotide, Middle Aged, Logistic Models, Treatment Outcome, Haplotypes, Pharmacogenetics, Case-Control Studies, Female, Hydroxymethylglutaryl-CoA Reductase Inhibitors
EMC NIHES-01-64-03, Male, ATP Binding Cassette Transporter, Subfamily B, EMC NIHES-01-64-02, EMC NIHES-03-77-02, Myocardial Infarction, Organic Anion Transporters, Polymorphism, Single Nucleotide, Medical Records, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Polymorphism, P-Glycoproteins, Liver-Specific Organic Anion Transporter 1, Incidence, P-Glycoprotein, Single Nucleotide, Middle Aged, Logistic Models, Treatment Outcome, Haplotypes, Pharmacogenetics, Case-Control Studies, Female, Hydroxymethylglutaryl-CoA Reductase Inhibitors
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