cDNA cloning and regional distribution of a novel member of the opioid receptor family
Copyright policy )cDNA cloning and regional distribution of a novel member of the opioid receptor family
We have cloned a cDNA for a novel member of the opioid receptor family, designated as ROR‐C, from the rat cerebrum cDNA library using the probe derived from the δ‐opioid receptor subtype cDNA. The deduced amino acid sequence of ROR‐C shows high homology with those of ROR‐A (rat δ‐opioid receptor subtype), ROR‐B (rat μ‐subtype) and ROR‐D (rat k‐subtype). RNA blot hybridization and in situ hybridization analysis revealed that ROR‐C mRNA is expressed in discrete regions of the rat central nervous system.
- International Institute for Advanced Studies Japan
- Kyoto University Japan
- International Institute of Minnesota United States
- Kyoto University Hospital Japan
- Kansai Medical University Japan
DNA, Complementary, G-protein-coupled receptor, Sequence Homology, Amino Acid, Molecular Sequence Data, Hypothalamus, Rat brain, Nuclear Receptor Subfamily 1, Group F, Member 3, Rats, Hybridization analysis (in situ), Receptors, Opioid, cDNA cloning, Animals, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Opioid receptor, RNA blot hybridization analysis, Cells, Cultured, In Situ Hybridization, Brain Stem
DNA, Complementary, G-protein-coupled receptor, Sequence Homology, Amino Acid, Molecular Sequence Data, Hypothalamus, Rat brain, Nuclear Receptor Subfamily 1, Group F, Member 3, Rats, Hybridization analysis (in situ), Receptors, Opioid, cDNA cloning, Animals, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Opioid receptor, RNA blot hybridization analysis, Cells, Cultured, In Situ Hybridization, Brain Stem
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