CLAN, a Novel Human CED-4-like Gene
Copyright policy )CLAN, a Novel Human CED-4-like Gene
Proteins governing cell death form the basis of many normal processes and contribute to the pathogenesis of many diseases when dysregulated. Here we report the cloning of a novel human CED-4-like gene, CLAN, and several of its alternatively spliced isoforms. These caspase-associated recruitment domain (CARD)-containing proteins are expressed at varying degrees in normal human tissues and may contribute to a number of intracellular processes including apoptosis, cytokine processing, and NF-kappa B activation. The CARD of the CLAN proteins binds a number of other CARD-containing proteins including caspase-1, BCL10, NOD2, and NAC. Once their physiologic functions are uncovered, CLAN proteins may prove to be valuable therapeutic targets.
- Sanford Burnham Prebys Medical Discovery Institute United States
DNA, Complementary, Models, Genetic, Calcium-Binding Proteins, Molecular Sequence Data, NF-kappa B, Nucleic Acid Hybridization, Apoptosis, Helminth Proteins, Precipitin Tests, CARD Signaling Adaptor Proteins, Caspases, Chromosomes, Human, Pair 2, Humans, Protein Isoforms, Electrophoresis, Polyacrylamide Gel, Amino Acid Sequence, Cloning, Molecular, Apoptosis Regulatory Proteins, Caenorhabditis elegans Proteins, Plasmids
DNA, Complementary, Models, Genetic, Calcium-Binding Proteins, Molecular Sequence Data, NF-kappa B, Nucleic Acid Hybridization, Apoptosis, Helminth Proteins, Precipitin Tests, CARD Signaling Adaptor Proteins, Caspases, Chromosomes, Human, Pair 2, Humans, Protein Isoforms, Electrophoresis, Polyacrylamide Gel, Amino Acid Sequence, Cloning, Molecular, Apoptosis Regulatory Proteins, Caenorhabditis elegans Proteins, Plasmids
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