The C-Terminal Domain of the Sudan Ebolavirus L Protein Is Essential for RNA Binding and Methylation
Copyright policy )The C-Terminal Domain of the Sudan Ebolavirus L Protein Is Essential for RNA Binding and Methylation
Ebola virus infects human and nonhuman primates, causing severe infections that are often fatal. The epidemics, in West and Central Africa, emphasize the urgent need to develop antiviral therapies. The Ebola virus large protein (L), which is the central protein for viral RNA replication/transcription, harbors a methyltransferase domain followed by a C-terminal domain of unknown function. We show that the C-terminal domain regulates the L protein methyltransferase activities and consequently participates in viral replication and escape of the host innate immunity.
Models, Molecular, Protein Conformation, alpha-Helical, 570, NS5, Gene Expression, Methylation, CAPPING ENZYME, Protein Domains, Escherichia coli, Humans, Protein Interaction Domains and Motifs, TRANSCRIPTION, Amino Acid Sequence, Cloning, Molecular, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, IDENTIFICATION, Base Sequence, POLYMERASE, VESICULAR STOMATITIS-VIRUS, Methyltransferases, Ebolavirus, RNA-Dependent RNA Polymerase, CAP, Recombinant Proteins, Gene Expression Regulation, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, REPLICATION, Host-Pathogen Interactions, RNA, Viral, Protein Conformation, beta-Strand, MESSENGER-RNA, METHYLTRANSFERASE DOMAIN, Protein Binding
Models, Molecular, Protein Conformation, alpha-Helical, 570, NS5, Gene Expression, Methylation, CAPPING ENZYME, Protein Domains, Escherichia coli, Humans, Protein Interaction Domains and Motifs, TRANSCRIPTION, Amino Acid Sequence, Cloning, Molecular, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, IDENTIFICATION, Base Sequence, POLYMERASE, VESICULAR STOMATITIS-VIRUS, Methyltransferases, Ebolavirus, RNA-Dependent RNA Polymerase, CAP, Recombinant Proteins, Gene Expression Regulation, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, REPLICATION, Host-Pathogen Interactions, RNA, Viral, Protein Conformation, beta-Strand, MESSENGER-RNA, METHYLTRANSFERASE DOMAIN, Protein Binding
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