Control of axon–axon attraction by Semaphorin reverse signaling
Copyright policy )Control of axon–axon attraction by Semaphorin reverse signaling
Significance Bidirectional signaling between ligand and receptor facilitates cell–cell communication. Recent studies show that members of the well-known Semaphorin family proteins can mediate both forward and reverse signaling in regulating neural network formation. In this study, we identify new components of the Semaphorin reverse signaling pathway and reveal a novel mechanism by which Semaphorin reverse signaling promotes axon–axon attraction in patterning neuronal circuitry during development.
- McGill University Health Centre Canada
- McGill University Canada
rho GTP-Binding Proteins, Cell Adhesion Molecules, Neuronal, Cell Membrane, Down-Regulation, Semaphorins, Axons, Drosophila melanogaster, Phenotype, Cell Adhesion, Animals, Drosophila Proteins, Phosphorylation, Cells, Cultured, Protein Binding, Signal Transduction
rho GTP-Binding Proteins, Cell Adhesion Molecules, Neuronal, Cell Membrane, Down-Regulation, Semaphorins, Axons, Drosophila melanogaster, Phenotype, Cell Adhesion, Animals, Drosophila Proteins, Phosphorylation, Cells, Cultured, Protein Binding, Signal Transduction
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