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CC chemokine receptor 5 polymorphism in Italian patients with giant cell arteritis
Copyright policy ) Pazzola, Giulia; Boiardi, Luigi; Casali, Bruno; Farnetti, Enrico; Nicoli, Davide; Pipitone, Nicolò; Padovano, Ilaria; +3 Authors
Pazzola, Giulia; Boiardi, Luigi; Casali, Bruno; Farnetti, Enrico; Nicoli, Davide; Pipitone, Nicolò; Padovano, Ilaria; Caruso, Andrea; Catanoso, Mariagrazia; SALVARANI, CARLO;
CC chemokine receptor 5 polymorphism in Italian patients with giant cell arteritis
To evaluate the potential role of CC chemokine receptor 5 (CCR5)Δ32 polymorphism in the susceptibility to giant cell arteritis (GCA) in a cohort of Italian patients.176 consecutive Italian patients with biopsy-proven GCA and 180 healthy age- and sex-matched blood donors were molecularly genotyped for the CCR5Δ32 polymorphism.No statistically significant difference in the Δ32CCR5 allele frequency between GCA patients (5.1 %) and controls (2.8 %) was observed (p = 0.109). Carriers of the CCR5Δ32 allele (Δ32/Δ32 + CCR5/Δ32) were similarly represented in the two groups.Our results do not support a role for the CCR5Δ32 polymorphism in determining susceptibility to GCA.
Aged, 80 and over, Male, Polymorphism, Genetic, Genotype, Receptors, CCR5, Giant Cell Arteritis, Middle Aged, Gene Frequency, Italy, Humans, Female, Genetic Predisposition to Disease, Aged; Aged, 80 and over; Alleles; Female; Gene Frequency; Giant Cell Arteritis; Humans; Italy; Male; Middle Aged; Receptors, CCR5; Genetic Predisposition to Disease; Genotype; Polymorphism, Genetic, Alleles, Aged
Aged, 80 and over, Male, Polymorphism, Genetic, Genotype, Receptors, CCR5, Giant Cell Arteritis, Middle Aged, Gene Frequency, Italy, Humans, Female, Genetic Predisposition to Disease, Aged; Aged, 80 and over; Alleles; Female; Gene Frequency; Giant Cell Arteritis; Humans; Italy; Male; Middle Aged; Receptors, CCR5; Genetic Predisposition to Disease; Genotype; Polymorphism, Genetic, Alleles, Aged
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).4 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average views 83 - 83views
citations
Citations provided by BIP!
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP!influenceInfluence provided by BIP!
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Influence provided by BIP!impulseImpulse provided by BIP!
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
Impulse provided by BIP!viewsViews provided by UsageCounts
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83