Homeo box gene complex on mouse chromosome 11: Molecular cloning, expression in embryogenesis, and homology to a human homeo box locus
Copyright policy )Homeo box gene complex on mouse chromosome 11: Molecular cloning, expression in embryogenesis, and homology to a human homeo box locus
The homeo box is a 180 bp protein-coding domain found within homeotic genes of Drosophila and conserved in a variety of invertebrate and vertebrate species. It has been suggested that the mammalian homeo box sequences may play a role in controlling pattern formation during embryogenesis. We report findings that support this hypothesis. We have cloned three overlapping recombinant phage clones that cover a region of mouse chromosome 11 that contains a cluster of four homeo boxes (the Hox-2 locus). This locus encodes multiple transcripts that are expressed during embryogenesis. Forty kilobases of the Hox-2 region is devoid of repetitive elements and shows extensive homology with the human Hox-2 locus. These results provide direct evidence for genetic expression during embryonic development, a conserved organization in comparison to the cognate human locus, and a complexity of organization and transcript expression similar to that found in Drosophila.
- Yale University United States
Embryo, Nonmammalian, Transcription, Genetic, Genetic Linkage, Chromosome Mapping, Nucleic Acid Hybridization, DNA Restriction Enzymes, Embryo, Mammalian, Mice, Genes, Sequence Homology, Nucleic Acid, Morphogenesis, Animals, Humans, Drosophila, Cloning, Molecular, Repetitive Sequences, Nucleic Acid
Embryo, Nonmammalian, Transcription, Genetic, Genetic Linkage, Chromosome Mapping, Nucleic Acid Hybridization, DNA Restriction Enzymes, Embryo, Mammalian, Mice, Genes, Sequence Homology, Nucleic Acid, Morphogenesis, Animals, Humans, Drosophila, Cloning, Molecular, Repetitive Sequences, Nucleic Acid
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