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Antimicrobial Agents and Chemotherapy
Article . 2019 . Peer-reviewed
License: ASM Journals Non-Commercial TDM
Data sources: Crossref
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The Diversity of the Plasmodium falciparum K13 Propeller Domain Did Not Increase after Implementation of Artemisinin-Based Combination Therapy in Uganda

Authors: Conrad, Melissa D; Nsobya, Sam L; Rosenthal, Philip J;

The Diversity of the Plasmodium falciparum K13 Propeller Domain Did Not Increase after Implementation of Artemisinin-Based Combination Therapy in Uganda

Abstract

Artemisinin-based combination therapies (ACTs) are the standard of care to treat uncomplicated falciparum malaria. However, resistance to artemisinins, defined as delayed parasite clearance after therapy, has emerged in Southeast Asia, and the spread of resistance to sub-Saharan Africa could have devastating consequences.

Keywords

Falciparum, Clinical Sciences, Plasmodium falciparum, Protozoan Proteins, 610, artemisinin resistance, Microbiology, Polymorphism, Single Nucleotide, Antimalarials, Rare Diseases, Genetics, 2.2 Factors relating to the physical environment, Humans, Uganda, Polymorphism, Malaria, Falciparum, Codon, K13, Biomedical and Clinical Sciences, Single Nucleotide, DNA, Pharmacology and Pharmaceutical Sciences, Sequence Analysis, DNA, Medical microbiology, Artemisinins, Malaria, Vector-Borne Diseases, Infectious Diseases, Good Health and Well Being, Pharmacology and pharmaceutical sciences, Haplotypes, Medical Microbiology, Mutation, Antimicrobial Resistance, Infection, Sequence Analysis

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    11
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
11
Top 10%
Average
Top 10%
Green
bronze