Downregulation of CCR5 Expression on the Peripheral Blood CD8+ T Cells of Southeastern Iranian Patients with Chronic Hepatitis B Infection
Copyright policy )Downregulation of CCR5 Expression on the Peripheral Blood CD8+ T Cells of Southeastern Iranian Patients with Chronic Hepatitis B Infection
Studies indicated that CC receptor 5 (CCR5), as a receptor for CC ligand 3, CCL4, and CCL5, plays important roles in the recruitment of T cytotoxic lymphocytes to the liver of chronic HBV (CHB)-infected patients. The main purpose of this study was to investigate the expression levels of CCR5 on the CD8(+) T lymphocytes of CHB patients. This clinical study was performed on 63 CHB patients and 96 healthy controls. Flow cytometric analysis was performed to examine the expression of CCR5 on CD8(+) T cells of CHB patients. Real-time PCR was also used for HBV-DNA quantification. The results of our study demonstrated that CCR5 expressing T cytotoxic cells were decreased significantly in CHB patients in comparison to healthy control. Based on our results, it can be concluded that the percent of CCR5(+)/CD8(+) T cells in Iranian CHB patients is significantly decreased, hence their migration to the infected liver, and HBV eradication from the hepatocytes is disrupted.
- Griffith University Australia
- Rafsanjan University of Medical Sciences Iran (Islamic Republic of)
- Kerman University of Medical Sciences Iran (Islamic Republic of)
Adult, Male, Hepatitis B virus, Receptors, CCR5, Immunology, Down-Regulation, Gene Expression, CD8-Positive T-Lymphocytes, Iran, Hepatitis B, Chronic, Liver Function Tests, Cell Movement, Humans, Aspartate Aminotransferases, Alanine Transaminase, Bilirubin, Alkaline Phosphatase, Liver, DNA, Viral, Infectious diseases, Female, T-Lymphocytes, Cytotoxic
Adult, Male, Hepatitis B virus, Receptors, CCR5, Immunology, Down-Regulation, Gene Expression, CD8-Positive T-Lymphocytes, Iran, Hepatitis B, Chronic, Liver Function Tests, Cell Movement, Humans, Aspartate Aminotransferases, Alanine Transaminase, Bilirubin, Alkaline Phosphatase, Liver, DNA, Viral, Infectious diseases, Female, T-Lymphocytes, Cytotoxic
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).14 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!