Nucleotide sequences of class-switch recombination region of the mouse immunoglobulin λ2b-chain gene
Copyright policy )Nucleotide sequences of class-switch recombination region of the mouse immunoglobulin λ2b-chain gene
We have cloned a rearranged gamma 2b-chain gene from mouse myeloma MOPC141. Nucleotide-sequence determination demonstrated that the rearranged gamma 2b-chain gene was formed by a recombination between the region flanking the 5'-ends of the embryonic mu-chain gene and that of the gamma 2b-chain genes. Nucleotide sequences similar to the one located adjacent to the recombination site were found in other parts of the region flanking the 5'-end of the mu-chain-gene, as well as in the region flanking the 5'-end of the gamma 1-chain gene. The common sequence (GGTANNAAAGNAC) shares extensive homology with the sequence proximal to the insertion site of the bacterial insertion element IS2.
- University of Tokyo Japan
Recombination, Genetic, Base Sequence, DNA, Recombinant, Chromosome Mapping, DNA, Cell Line, Mice, Myeloma Proteins, Genes, Animals, Cloning, Molecular, Protein Precursors, Multiple Myeloma
Recombination, Genetic, Base Sequence, DNA, Recombinant, Chromosome Mapping, DNA, Cell Line, Mice, Myeloma Proteins, Genes, Animals, Cloning, Molecular, Protein Precursors, Multiple Myeloma
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